Ciprofloxacin
Injection (0.2%) |
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Therapeutic Category
: Fluoroquinolone
Composition : Each 100ml of
solution contains
1. Ciprofloxacin hydrochloride USP equivalent
to Ciprofloxacin 200mg (as lactate)
Pharmacology : Ciprofloxacin
is a fluoroquinolone, and like other members of
its class, it inhibits bacterial enzymes, DNA
gyrase and DNA ligase. These enzymes are essential
in the replication of bacterial DNA, without which
protein synthesis comes to a halt, inhibition
of protein synthesis leads to bacterial death
and lysis.
Indications : Ciprofloxacin
is indicated in the treatment of wide variety
of mixed infections caused by sensitive Gram-positive
and Gram-negative organisms. Ciprofloxacin Injection
is used if oral therapy is ineffective or not
possible, in the treatment of severe forms of
the following infections :
- Infections of the upper and lower respiratory
tract e.g. however, infections due to Streptococcus
pneumoniae or Streptococcus pyogenes, may
require a higher dose.
- Infections of urinary tract.
- Gonorrhoea, including urethral, rectal and
pharyngeal infections even due to strains
of PPNG/CMNG.
- Dermal and intradermal infections including
those following burns.
- Infections of gastro-intestinal tract including
typhoid and paratyphoid.
- Gynaecological infections (e.g. salpingitis
and endometritis).
- Bone and joint infections (e.g. acute and
chronic osteomyelitis, septic arthritis).
- Serious systemic infections (e.g. septicaemia,
bacteraemia and in immuno-compromised patients).
- Surgical infections with nosocomial bacteria.
- Surgical prophylaxis
- Multi drug resistant Tuberculosis along
with other Anti T.B drugs.
Dosage Adults
- The dosage of Ciprofloxacin is determined on
the basis of severity of infection, type of infecting
organism and age, weight and renal function of
the patient. The physician, may decide the dosage
to be used and the duration of therapy, keeping
in view the response of the patient. IV infusion
should be administered slowly, with 100 ml being
infused over a period of 30 to 60 minutes.
Children - It is generally not
recommended if other drugs are available. However
compassionate use, and use under emergency conditions
has shown that its risk in children has been overrated.
Adverse Effects : Nausea, epigastric
distress, headache vomiting, diarrhoea, restlessness,
and abdominal pain, skin rash and arthralgia.
Presentation : Injection bottle
of 100ml
Storage : Store at a temperature
upto 25oC, protected from light. Do
not freeze. Keep out of the reach of children.
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