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Therapeutic Category : Broad-spectrum cephalosporin antibiotic
Composition : Each vial contains
Ceftriaxone sodium BP equivalent to Ceftriaxone 1.0g BP
Pharmacology : Ceftriaxone works by inhibiting the mucopeptide synthesis in the bacterial cell wall.
The bactericidal activity of Ceftriaxone results from the inhibition of cell wall synthesis and is mediated through Ceftriaxone binding to penicillin binding proteins (PBPs). Ceftriaxone is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
Indications :
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Lower Respiratory tract infections
- Acute bacterial otitis media
- UTI
- Uncomplicated gonorrhea
- Pelvic inflammatory disease
- Bacterial septicemia
- Bone and Joint infections
- Intra abdominal infections
- Meningitis
- Surgical prophylaxis
- Skin and soft tissue infections
Dosage : Adults 1 to 2 grams given once a day (or in equally divided doses twice a day) depending on the type and severity of infection. The total daily dose should not exceed 4 grams.
Children : For the treatment of skin and skin structure infections, the recommended total daily dose is 50 to 75 mg/kg given once a day (or in equally divided doses twice a day). The total daily dose should not exceed 2 grams.
Contraindications : Hypersensitivity to cephalosporins or penicillins.
Adverse Effects: Abdominal pain, agranulocytosis, anaphylaxis, basophilia, bronchospasm, colitis, dyspepsia, epistaxis, flatulence, palpitations, a decrease in the prothrombin time and serum sickness.
Presentation : Vial containing 1g of Ceftriaxone.
Storage : Store at temperature not more than 30° C, in a dry place protected from light.
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